Mast Cell-Airway Smooth Muscle Crosstalk
نویسندگان
چکیده
T-helper cell type 2 (Th2) polarization of the infl ammatory response is an important component of the asthma paradigm. 5,6 A major effector axis resulting in this polarization is the recognition of allergen presented by dendritic cells in local lymph nodes to the CD4 1 T cell. The differentiation of naive T cells or reactivation of memory T cells is dependent upon costimulatory molecules, such as OX40, and their cognate ligand OX40L, 5-10 which is increased in the
منابع مشابه
Nerve-mast cell and smooth muscle-mast cell interaction mediated by cell adhesion molecule-1, CADM1.
Mast cells are a native composer of connective tissue of the skin dermis and intestinal and respiratory mucosa. Independent lines of accumulated evidence indicate the existence of an intensive bidirectional crosstalk between mast cells and sensory nerves and suggest that mast cells and sensory nerves may be viewed as a functional unit, which could be of crucial importance in neuroimmunological ...
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